A Role for cis Interaction between the Inhibitory Ly49A receptor and MHC class I for natural killer cell education.

Détails

ID Serval
serval:BIB_891F521C981B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A Role for cis Interaction between the Inhibitory Ly49A receptor and MHC class I for natural killer cell education.
Périodique
Immunity
Auteur(s)
Chalifour A., Scarpellino L., Back J., Brodin P., Devèvre E., Gros F., Lévy F., Leclercq G., Höglund P., Beermann F., Held W.
ISSN
1097-4180[electronic]
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
30
Numéro
3
Pages
337-347
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Natural killer (NK) cells show enhanced functional competence when they express inhibitory receptors specific for inherited major histocompatibility complex class I (MHC-I) molecules. Current models imply that NK cell education requires an interaction of inhibitory receptors with MHC-I expressed on other cells. However, the inhibitory Ly49A receptor can also bind MHC-I ligand on the NK cell itself (in cis). Here we describe a Ly49A variant, which can engage MHC-I expressed on other cells but not in cis. Even though this variant inhibited NK cell effector function, it failed to educate NK cells. The association with MHC-I in cis sequestered wild-type Ly49A, and this was found to relieve NK cells from a suppressive effect of unengaged Ly49A. These data explain how inhibitory MHC-I receptors can facilitate NK cell activation. They dissociate classical inhibitory from educating functions of Ly49A and suggest that cis interaction of Ly49A is necessary for NK cell education.
Mots-clé
Animals, Cell Line, Tumor, Cells, Cultured, Flow Cytometry, Genetic Variation, Histocompatibility Antigens Class I/metabolism, Killer Cells, Natural/immunology, Lymphocyte Activation/immunology, Mice, Mice, Inbred C57BL, NK Cell Lectin-Like Receptor Subfamily A/genetics, NK Cell Lectin-Like Receptor Subfamily A/metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
19/01/2010 15:52
Dernière modification de la notice
20/08/2019 14:48
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