A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_852F74DC799C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion.
Journal
Cell metabolism
Author(s)
Ferrero R., Rainer P.Y., Rumpler M., Russeil J., Zachara M., Pezoldt J., van Mierlo G., Gardeux V., Saelens W., Alpern D., Favre L., Vionnet N., Mantziari S., Zingg T., Pitteloud N., Suter M., Matter M., Schlaudraff K.U., Canto C., Deplancke B.
ISSN
1932-7420 (Electronic)
ISSN-L
1550-4131
Publication state
Published
Issued date
02/07/2024
Peer-reviewed
Oui
Volume
36
Number
7
Pages
1566-1585.e9
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Adipose tissue plasticity is orchestrated by molecularly and functionally diverse cells within the stromal vascular fraction (SVF). Although several mouse and human adipose SVF cellular subpopulations have by now been identified, we still lack an understanding of the cellular and functional variability of adipose stem and progenitor cell (ASPC) populations across human fat depots. To address this, we performed single-cell and bulk RNA sequencing (RNA-seq) analyses of >30 SVF/Lin- samples across four human adipose depots, revealing two ubiquitous human ASPC (hASPC) subpopulations with distinct proliferative and adipogenic properties but also depot- and BMI-dependent proportions. Furthermore, we identified an omental-specific, high IGFBP2-expressing stromal population that transitions between mesothelial and mesenchymal cell states and inhibits hASPC adipogenesis through IGFBP2 secretion. Our analyses highlight the molecular and cellular uniqueness of different adipose niches, while our discovery of an anti-adipogenic IGFBP2+ omental-specific population provides a new rationale for the biomedically relevant, limited adipogenic capacity of omental hASPCs.
Keywords
Humans, Adipogenesis, Omentum/metabolism, Omentum/cytology, Insulin-Like Growth Factor Binding Protein 2/metabolism, Insulin-Like Growth Factor Binding Protein 2/genetics, Stromal Cells/metabolism, Stromal Cells/cytology, Female, Male, Middle Aged, Adipose Tissue/metabolism, Adipose Tissue/cytology, Adult, Epithelium/metabolism, Stem Cells/metabolism, Stem Cells/cytology, Mesenchymal Stem Cells/metabolism, Mesenchymal Stem Cells/cytology, Aged, Animals, Human adipose tissue, IGFBP2, adipogenesis, adipose stem and progenitor cells, anti-adipogenic, mesothelial cells, mesothelial to mesenchymal transition, omentum, scRNA-seq, visceral adipose tissue
Pubmed
Web of science
Open Access
Yes
Create date
17/05/2024 8:17
Last modification date
26/07/2024 6:13
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