Article: article from journal or magazin.
La rate: entre mystères et découvertes [The spleen: between mysteries and discoveries].
Revue Médicale Suisse
Publication types: English Abstract ; Journal ArticlePublication Status: ppublish
Mainly because it is possible to live without it, the spleen has always been considered a secondary and mysterious organ. However, recent observations have revealed new unsuspected functions for this organ whose patho-physiological importance should be reconsidered. Much less known than the hypersplenism, the hyposplenism corresponds historically to the loss or the insufficiency of the two principal functions of spleen: the filtration of faded or senescent elements from the blood and the fight against infections. In this article, after a short recall of the physiological functions of spleen, three innovations relating to hyposplenism will be explored: the vascular complications, the loss of the splenic pool of regenerating monocytes and the loss of the splenic pool of pluripotent mesenchymal stem cell.
Algorithms, Atherosclerosis/physiopathology, Humans, Mesenchymal Stem Cells, Monocytes/metabolism, Phagocytosis, Risk Factors, Spleen/blood supply, Spleen/physiology, Splenic Diseases/blood, Splenic Diseases/complications, Thromboembolism/physiopathology
Last modification date