Lack of multiple copies of pfmdr1 gene in Papua New Guinea.

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Serval ID
serval:BIB_8225DFE89ED7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Production externe
Title
Lack of multiple copies of pfmdr1 gene in Papua New Guinea.
Journal
Transactions of the Royal Society of Tropical Medicine and Hygiene
Author(s)
Hodel E.M., Marfurt J., Müller D., Rippert A., Borrmann S., Müller I., Reeder J.C., Siba P., Genton B., Beck H.P.
ISSN
1878-3503[electronic], 0035-9203[linking]
Publication state
Published
Issued date
2008
Volume
102
Number
11
Pages
1151-1153
Language
english
Abstract
We describe here the results of an analysis of Plasmodium falciparum multidrug resistance protein 1 (pfmdr1) gene copy number from 440 field isolates from Papua New Guinea. No multiple copies of the gene were found, which corresponds to the lack of usage of mefloquine. These data extend regional knowledge about the distribution of multidrug-resistant P. falciparum.
Keywords
Animals, Antimalarials/therapeutic use, Artemisinins/therapeutic use, Drug Resistance/genetics, Genes, MDR/genetics, Genotype, Humans, Malaria, Falciparum/drug therapy, Malaria, Falciparum/genetics, Mefloquine/therapeutic use, Multidrug Resistance-Associated Proteins/genetics, Papua New Guinea, Plasmodium falciparum/drug effects, Plasmodium falciparum/genetics, Polymorphism, Genetic
DOI
10.1016/j.trstmh.2008.05.017
Pubmed
18599099
Create date
03/07/2010 9:15
Last modification date
20/08/2019 15:42
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