Lack of multiple copies of pfmdr1 gene in Papua New Guinea.

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ID Serval
serval:BIB_8225DFE89ED7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Production externe
Titre
Lack of multiple copies of pfmdr1 gene in Papua New Guinea.
Périodique
Transactions of the Royal Society of Tropical Medicine and Hygiene
Auteur⸱e⸱s
Hodel E.M., Marfurt J., Müller D., Rippert A., Borrmann S., Müller I., Reeder J.C., Siba P., Genton B., Beck H.P.
ISSN
1878-3503[electronic], 0035-9203[linking]
Statut éditorial
Publié
Date de publication
2008
Volume
102
Numéro
11
Pages
1151-1153
Langue
anglais
Résumé
We describe here the results of an analysis of Plasmodium falciparum multidrug resistance protein 1 (pfmdr1) gene copy number from 440 field isolates from Papua New Guinea. No multiple copies of the gene were found, which corresponds to the lack of usage of mefloquine. These data extend regional knowledge about the distribution of multidrug-resistant P. falciparum.
Mots-clé
Animals, Antimalarials/therapeutic use, Artemisinins/therapeutic use, Drug Resistance/genetics, Genes, MDR/genetics, Genotype, Humans, Malaria, Falciparum/drug therapy, Malaria, Falciparum/genetics, Mefloquine/therapeutic use, Multidrug Resistance-Associated Proteins/genetics, Papua New Guinea, Plasmodium falciparum/drug effects, Plasmodium falciparum/genetics, Polymorphism, Genetic
DOI
10.1016/j.trstmh.2008.05.017
Pubmed
18599099
Création de la notice
03/07/2010 9:15
Dernière modification de la notice
20/08/2019 15:42
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