Risk and benefit of low systemic heparinization during open heart operations
Details
Serval ID
serval:BIB_81A27CF3D9A4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Risk and benefit of low systemic heparinization during open heart operations
Journal
Annals of Thoracic Surgery
ISSN
0003-4975
Publication state
Published
Issued date
08/1994
Peer-reviewed
Oui
Volume
58
Number
2
Pages
391-7; discussion 398
Notes
Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Aug
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Aug
Abstract
Heparin surface-coated perfusion equipment with improved thromboresistance was evaluated in 104 consecutive patients undergoing open heart operation in a prospective, randomized trial with low versus full systemic heparinization. Surgical procedures included coronary artery revascularization in 47 of 54 (87%) for low versus 44 of 50 patients (88%; not significant [NS]) for full, valve repair/replacement in 8 of 54 (15%) for low versus 5 of 50 patients (10%; NS) for full, left ventricular aneurysm repair in 1 of 54 (2%) for low versus 2 of 50 patients (4%; NS) for full, and other in 3 of 54 (6%) for low versus 3 of 50 patients (6%; NS) for full. Cross-clamp time was 39.2 +/- 10.7 minutes for low versus 39.5 +/- 10.5 minutes for full (NS). Cardiopulmonary bypass time was 68.6 +/- 20.1 minutes for low versus 69.3 +/- 16.6 minutes for full (NS). Lowest activated coagulation time during perfusion was 255 +/- 75 seconds for low versus 537 +/- 205 seconds for full (p < 0.0005). In the low group, the target activated coagulation time of more than 180 seconds was not reached during perfusion in 4 of 54 patients (7%), the lowest value being 164 seconds. No oxygenator failure occurred. Hospital mortality was 0 of 54 (0%) for low versus 1 of 50 patients (2%) for full (NS). Bleeding required surgical revision in 0 of 54 (0%) for low versus 4 of 50 patients (8%) for full (p = 0.05). Drainage (24 hours) was 790 +/- 393 mL for low versus 1,039 +/- 732 mL for full (p < 0.025).(ABSTRACT TRUNCATED AT 250 WORDS)
Keywords
Blood Coagulation/drug effects
Blood Loss, Surgical
Blood Transfusion
*Cardiac Surgical Procedures
Cardiopulmonary Bypass/instrumentation
Female
Heparin/*administration & dosage
Hospital Mortality
Humans
Male
Middle Aged
Postoperative Complications
Prospective Studies
Surface Properties
Pubmed
Web of science
Create date
14/02/2008 15:15
Last modification date
20/08/2019 15:41