Risk and benefit of low systemic heparinization during open heart operations

Détails

ID Serval
serval:BIB_81A27CF3D9A4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Risk and benefit of low systemic heparinization during open heart operations
Périodique
Annals of Thoracic Surgery
Auteur⸱e⸱s
von Segesser  L. K., Weiss  B. M., Pasic  M., Garcia  E., Turina  M. I.
ISSN
0003-4975
Statut éditorial
Publié
Date de publication
08/1994
Peer-reviewed
Oui
Volume
58
Numéro
2
Pages
391-7; discussion 398
Notes
Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Aug
Résumé
Heparin surface-coated perfusion equipment with improved thromboresistance was evaluated in 104 consecutive patients undergoing open heart operation in a prospective, randomized trial with low versus full systemic heparinization. Surgical procedures included coronary artery revascularization in 47 of 54 (87%) for low versus 44 of 50 patients (88%; not significant [NS]) for full, valve repair/replacement in 8 of 54 (15%) for low versus 5 of 50 patients (10%; NS) for full, left ventricular aneurysm repair in 1 of 54 (2%) for low versus 2 of 50 patients (4%; NS) for full, and other in 3 of 54 (6%) for low versus 3 of 50 patients (6%; NS) for full. Cross-clamp time was 39.2 +/- 10.7 minutes for low versus 39.5 +/- 10.5 minutes for full (NS). Cardiopulmonary bypass time was 68.6 +/- 20.1 minutes for low versus 69.3 +/- 16.6 minutes for full (NS). Lowest activated coagulation time during perfusion was 255 +/- 75 seconds for low versus 537 +/- 205 seconds for full (p < 0.0005). In the low group, the target activated coagulation time of more than 180 seconds was not reached during perfusion in 4 of 54 patients (7%), the lowest value being 164 seconds. No oxygenator failure occurred. Hospital mortality was 0 of 54 (0%) for low versus 1 of 50 patients (2%) for full (NS). Bleeding required surgical revision in 0 of 54 (0%) for low versus 4 of 50 patients (8%) for full (p = 0.05). Drainage (24 hours) was 790 +/- 393 mL for low versus 1,039 +/- 732 mL for full (p < 0.025).(ABSTRACT TRUNCATED AT 250 WORDS)
Mots-clé
Blood Coagulation/drug effects Blood Loss, Surgical Blood Transfusion *Cardiac Surgical Procedures Cardiopulmonary Bypass/instrumentation Female Heparin/*administration & dosage Hospital Mortality Humans Male Middle Aged Postoperative Complications Prospective Studies Surface Properties
Pubmed
Web of science
Création de la notice
14/02/2008 14:15
Dernière modification de la notice
20/08/2019 14:41
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