Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
Chickenpox is not always benign: postvaricella purpura fulminans requires prompt and aggressive treatment.
Pediatric Emergency Care
Publication types: Case Reports ; Journal Article Publication Status: ppublish
We present 2 patients, who were admitted owing to rapidly progressing purpuric lesions due to postvaricella purpura fulminans, a coagulopathy leading to life- or limb-threatening thrombosis caused by a severe transient autoimmune protein S deficiency. Laboratory results were being consistent with disseminated intravascular coagulation secondary to protein S deficiency; treatment with fresh frozen plasma, intravenous immunoglobulins, and prednisone was started. In our experience, a prompt therapy may limit the course and the extent of the disease. We present a review of the topic with supporting literature for the therapeutic options. Therefore, we should be reminded that purpura fulminans is a rare but severe complication of chickenpox, which demands quick action.
Antigens, Viral/immunology, Autoimmune Diseases/etiology, Chickenpox/complications, Child, Preschool, Combined Modality Therapy, Diagnosis, Differential, Disseminated Intravascular Coagulation/diagnosis, Disseminated Intravascular Coagulation/drug therapy, Female, Herpes Zoster/immunology, Humans, Immunoglobulins, Intravenous/therapeutic use, Male, Models, Immunological, Molecular Mimicry, Plasma, Prednisone/therapeutic use, Protein S/immunology, Protein S Deficiency/diagnosis, Purpura Fulminans/diagnosis, Purpura Fulminans/drug therapy
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