Chickenpox is not always benign: postvaricella purpura fulminans requires prompt and aggressive treatment.

Détails

ID Serval
serval:BIB_80FF56BF5802
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Chickenpox is not always benign: postvaricella purpura fulminans requires prompt and aggressive treatment.
Périodique
Pediatric Emergency Care
Auteur(s)
Fluri S., Kaczala G.W., Leibundgut K., Alberio L.
ISSN
1535-1815 (Electronic)
ISSN-L
0749-5161
Statut éditorial
Publié
Date de publication
2010
Peer-reviewed
Oui
Volume
26
Numéro
12
Pages
932-934
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article Publication Status: ppublish
Résumé
We present 2 patients, who were admitted owing to rapidly progressing purpuric lesions due to postvaricella purpura fulminans, a coagulopathy leading to life- or limb-threatening thrombosis caused by a severe transient autoimmune protein S deficiency. Laboratory results were being consistent with disseminated intravascular coagulation secondary to protein S deficiency; treatment with fresh frozen plasma, intravenous immunoglobulins, and prednisone was started. In our experience, a prompt therapy may limit the course and the extent of the disease. We present a review of the topic with supporting literature for the therapeutic options. Therefore, we should be reminded that purpura fulminans is a rare but severe complication of chickenpox, which demands quick action.
Mots-clé
Antigens, Viral/immunology, Autoimmune Diseases/etiology, Chickenpox/complications, Child, Preschool, Combined Modality Therapy, Diagnosis, Differential, Disseminated Intravascular Coagulation/diagnosis, Disseminated Intravascular Coagulation/drug therapy, Female, Herpes Zoster/immunology, Humans, Immunoglobulins, Intravenous/therapeutic use, Male, Models, Immunological, Molecular Mimicry, Plasma, Prednisone/therapeutic use, Protein S/immunology, Protein S Deficiency/diagnosis, Purpura Fulminans/diagnosis, Purpura Fulminans/drug therapy
Pubmed
Web of science
Création de la notice
10/02/2015 12:23
Dernière modification de la notice
20/08/2019 15:41
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