Value of different clinical and biochemical correlates to assess angiotensin converting enzyme inhibition

Details

Serval ID
serval:BIB_80E9E055104C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Value of different clinical and biochemical correlates to assess angiotensin converting enzyme inhibition
Journal
Journal of Cardiovascular Pharmacology
Author(s)
Delacretaz  E., Nussberger  J., Puchler  K., Wood  A. J., Robinson  P. R., Waeber  B., Brunner  H. R.
ISSN
0160-2446 (Print)
Publication state
Published
Issued date
09/1994
Volume
24
Number
3
Pages
479-85
Notes
Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Sep
Abstract
In a double-blind study, we compared the value of different approaches to assess blockade of angiotensin (Ang) II generation in 10 normal volunteers treated with the new Ang-converting enzyme (ACE) inhibitor temocapril. Plasma concentration of the diacid active metabolite of temocapril, plasma Ang I and II levels, plasma ACE activity, and inhibition of the pressor response to repeated intravenous (i.v.) doses of Ang I were measured before and repeatedly after different doses of tempocapril or placebo. In vivo ACE activity, estimated by the plasma Ang II/Ang I ratio, correlated well with temocapril diacid concentration (r = 0.85, n = 148) and with systolic and diastolic blood pressure (SBP, DBP) responses to Ang I (r = 0.76 and r = 0.79, n = 148). SBP and DBP responses to Ang I were also strongly related to temocapril diacid concentration (r = -0.81 and r = -0.88, n = 148). ACE activity measured in vivo reliably predicts the decrease in Ang-dependent BP to be achieved by ACE inhibitors.
Keywords
Administration, Oral Adult Angiotensin I/administration & dosage/antagonists & inhibitors/blood/pharmacology Angiotensin II/blood Angiotensin-Converting Enzyme Inhibitors/administration & dosage/blood/*pharmacology Blood Pressure/*drug effects Dose-Response Relationship, Drug Double-Blind Method Drug Evaluation Humans Injections, Intravenous Male Reproducibility of Results Tablets Thiazepines/administration & dosage/blood/*pharmacology
Pubmed
Web of science
Create date
05/03/2008 16:41
Last modification date
20/08/2019 14:41
Usage data