Value of different clinical and biochemical correlates to assess angiotensin converting enzyme inhibition
Détails
ID Serval
serval:BIB_80E9E055104C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Value of different clinical and biochemical correlates to assess angiotensin converting enzyme inhibition
Périodique
Journal of Cardiovascular Pharmacology
ISSN
0160-2446 (Print)
Statut éditorial
Publié
Date de publication
09/1994
Volume
24
Numéro
3
Pages
479-85
Notes
Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Sep
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Sep
Résumé
In a double-blind study, we compared the value of different approaches to assess blockade of angiotensin (Ang) II generation in 10 normal volunteers treated with the new Ang-converting enzyme (ACE) inhibitor temocapril. Plasma concentration of the diacid active metabolite of temocapril, plasma Ang I and II levels, plasma ACE activity, and inhibition of the pressor response to repeated intravenous (i.v.) doses of Ang I were measured before and repeatedly after different doses of tempocapril or placebo. In vivo ACE activity, estimated by the plasma Ang II/Ang I ratio, correlated well with temocapril diacid concentration (r = 0.85, n = 148) and with systolic and diastolic blood pressure (SBP, DBP) responses to Ang I (r = 0.76 and r = 0.79, n = 148). SBP and DBP responses to Ang I were also strongly related to temocapril diacid concentration (r = -0.81 and r = -0.88, n = 148). ACE activity measured in vivo reliably predicts the decrease in Ang-dependent BP to be achieved by ACE inhibitors.
Mots-clé
Administration, Oral
Adult
Angiotensin I/administration & dosage/antagonists &
inhibitors/blood/pharmacology
Angiotensin II/blood
Angiotensin-Converting Enzyme Inhibitors/administration &
dosage/blood/*pharmacology
Blood Pressure/*drug effects
Dose-Response Relationship, Drug
Double-Blind Method
Drug Evaluation
Humans
Injections, Intravenous
Male
Reproducibility of Results
Tablets
Thiazepines/administration & dosage/blood/*pharmacology
Pubmed
Web of science
Création de la notice
05/03/2008 17:41
Dernière modification de la notice
20/08/2019 15:41