Deciphering and reversing tumor immune suppression.

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Ressource 1Download: BIB_7F10396A4568.P001.pdf (1361.97 [Ko])
State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_7F10396A4568
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Deciphering and reversing tumor immune suppression.
Journal
Immunity
Author(s)
Motz G.T., Coukos G.
ISSN
1097-4180 (Electronic)
ISSN-L
1074-7613
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
39
Number
1
Pages
61-73
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Review Publication Status: ppublishDocument Type: Review
Abstract
Generating an anti-tumor immune response is a multi-step process that is executed by effector T cells that can recognize and kill tumor targets. However, tumors employ multiple strategies to attenuate the effectiveness of T-cell-mediated attack. They achieve this by interfering with nearly every step required for effective immunity, from deregulation of antigen-presenting cells to establishment of a physical barrier at the vasculature that prevents homing of effector tumor-rejecting cells and the suppression of effector lymphocytes through the recruitment and activation of immunosuppressive cells such as myeloid-derived suppressor cells, tolerogenic monocytes, and T regulatory cells. Here, we review the ways in which tumors exert immune suppression and highlight the new therapies that seek to reverse this phenomenon and promote anti-tumor immunity. Understanding anti-tumor immunity, and how it becomes disabled by tumors, will ultimately lead to improved immune therapies and prolonged survival of patients.
Keywords
Antigen-Presenting Cells/immunology, Humans, Lymphocyte Activation/immunology, Models, Immunological, Myeloid Cells/immunology, Neoplasms/immunology, T-Lymphocytes, Cytotoxic/immunology, T-Lymphocytes, Regulatory/immunology
Pubmed
Web of science
Open Access
Yes
Create date
07/03/2014 19:42
Last modification date
20/08/2019 14:39
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