Deciphering and reversing tumor immune suppression.

Détails

Ressource 1Télécharger: BIB_7F10396A4568.P001.pdf (1361.97 [Ko])
Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_7F10396A4568
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Deciphering and reversing tumor immune suppression.
Périodique
Immunity
Auteur⸱e⸱s
Motz G.T., Coukos G.
ISSN
1097-4180 (Electronic)
ISSN-L
1074-7613
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
39
Numéro
1
Pages
61-73
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Review Publication Status: ppublishDocument Type: Review
Résumé
Generating an anti-tumor immune response is a multi-step process that is executed by effector T cells that can recognize and kill tumor targets. However, tumors employ multiple strategies to attenuate the effectiveness of T-cell-mediated attack. They achieve this by interfering with nearly every step required for effective immunity, from deregulation of antigen-presenting cells to establishment of a physical barrier at the vasculature that prevents homing of effector tumor-rejecting cells and the suppression of effector lymphocytes through the recruitment and activation of immunosuppressive cells such as myeloid-derived suppressor cells, tolerogenic monocytes, and T regulatory cells. Here, we review the ways in which tumors exert immune suppression and highlight the new therapies that seek to reverse this phenomenon and promote anti-tumor immunity. Understanding anti-tumor immunity, and how it becomes disabled by tumors, will ultimately lead to improved immune therapies and prolonged survival of patients.
Mots-clé
Antigen-Presenting Cells/immunology, Humans, Lymphocyte Activation/immunology, Models, Immunological, Myeloid Cells/immunology, Neoplasms/immunology, T-Lymphocytes, Cytotoxic/immunology, T-Lymphocytes, Regulatory/immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
07/03/2014 19:42
Dernière modification de la notice
20/08/2019 14:39
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