Article: article from journal or magazin.
Hyperpolarized lithium-6 as a sensor of nanomolar contrast agents.
Magnetic Resonance in Medicine
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Lithium is widely used in psychotherapy. The (6)Li isotope has a long intrinsic longitudinal relaxation time T(1) on the order of minutes, making it an ideal candidate for hyperpolarization experiments. In the present study we demonstrated that lithium-6 can be readily hyperpolarized within 30 min, while retaining a long polarization decay time on the order of a minute. We used the intrinsically long relaxation time for the detection of 500 nM contrast agent in vitro. Hyperpolarized lithium-6 was administered to the rat and its signal retained a decay time on the order of 70 sec in vivo. Localization experiments imply that the lithium signal originated from within the brain and that it was detectable up to 5 min after administration. We conclude that the detection of submicromolar contrast agents using hyperpolarized NMR nuclei such as (6)Li may provide a novel avenue for molecular imaging.
Animals, Brain/metabolism, Contrast Media/analysis, Contrast Media/pharmacokinetics, Isotopes/diagnostic use, Isotopes/pharmacokinetics, Lithium/diagnostic use, Lithium/pharmacokinetics, Magnetic Resonance Spectroscopy/methods, Male, Metabolic Clearance Rate, Molecular Probe Techniques, Molecular Probes, Nanostructures/chemistry, Radiopharmaceuticals/diagnostic use, Radiopharmaceuticals/pharmacokinetics, Rats, Rats, Sprague-Dawley
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