Experimental evolution of slowed cognitive aging in Drosophila melanogaster.

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Ressource 1Télécharger: Zwoinska_et_al 2017 Evolution.pdf (240.25 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_7CE03F32298D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Experimental evolution of slowed cognitive aging in Drosophila melanogaster.
Périodique
Evolution
Auteur(s)
Zwoinska M.K., Maklakov A.A., Kawecki T.J., Hollis B.
ISSN
1558-5646 (Electronic)
ISSN-L
0014-3820
Statut éditorial
Publié
Date de publication
2017
Peer-reviewed
Oui
Volume
71
Numéro
3
Pages
662-670
Langue
anglais
Résumé
Reproductive output and cognitive performance decline in parallel during aging, but it is unknown whether this reflects a shared genetic architecture or merely the declining force of natural selection acting independently on both traits. We used experimental evolution in Drosophila melanogaster to test for the presence of genetic variation for slowed cognitive aging, and assess its independence from that responsible for other traits' decline with age. Replicate experimental populations experienced either joint selection on learning and reproduction at old age (Old + Learning), selection on late-life reproduction alone (Old), or a standard two-week culture regime (Young). Within 20 generations, the Old + Learning populations evolved a slower decline in learning with age than both the Old and Young populations, revealing genetic variation for cognitive aging. We found little evidence for a genetic correlation between cognitive and demographic aging: although the Old + Learning populations tended to show higher late-life fecundity than Old populations, they did not live longer. Likewise, selection for late reproduction alone did not result in improved late-life learning. Our results demonstrate that Drosophila harbor genetic variation for cognitive aging that is largely independent from genetic variation for demographic aging and suggest that these two aspects of aging may not necessarily follow the same trajectories.

Pubmed
Web of science
Open Access
Oui
Création de la notice
29/12/2016 9:29
Dernière modification de la notice
08/05/2019 20:54
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