Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
Topical retinoic acid in dysplastic and metaplastic keratinization of corneoconjunctival epithelium
Graefe's Archive for Clinical and Experimental Ophthalmology
We report four cases of corneoconjunctival keratinization that were successfully treated with topical retinoic acid ointment. In two cases keratinization was due to squamous metaplasia and in two others it was secondary to intraepithelial corneoconjunctival neoplasia. Treatment reversed severe keratinization in a case of drug-induced pseudopemphigoid and stabilized the disease in one of the two affected eyes without additional treatment. In a case of ocular cicatricial pemphigoid, retinoic acid was useful as an adjuvant therapy to immunosuppression, by reversing keratinization of the conjunctiva. In two cases of corneoconjunctival neoplasia, lesions regressed markedly. Long-term treatment was well tolerated in three patients. Our findings suggest that retinoic acid ointment is effective in treating severe squamous metaplasia in cicatrizing diseases of the conjunctiva. Our findings indicate further that retinoic acid seems to inhibit growth of corneoconjunctival neoplasias and thus might be useful complementary therapy in this situation.
Administration, Topical Aged Aged, 80 and over Conjunctiva/*metabolism Conjunctival Diseases/*drug therapy/pathology Conjunctival Neoplasms/drug therapy Conjunctivitis/drug therapy/pathology Cornea/*metabolism Corneal Diseases/*drug therapy/pathology Epithelium/metabolism/pathology Female Humans Keratins/*metabolism Male Metaplasia/drug therapy Tretinoin/administration & dosage/*therapeutic use
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