Topical retinoic acid in dysplastic and metaplastic keratinization of corneoconjunctival epithelium
Details
Serval ID
serval:BIB_7CAEF3994365
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Topical retinoic acid in dysplastic and metaplastic keratinization of corneoconjunctival epithelium
Journal
Graefe's Archive for Clinical and Experimental Ophthalmology
ISSN
0721-832X (Print)
Publication state
Published
Issued date
1988
Volume
226
Number
1
Pages
22-6
Notes
Case Reports
Journal Article
Journal Article
Abstract
We report four cases of corneoconjunctival keratinization that were successfully treated with topical retinoic acid ointment. In two cases keratinization was due to squamous metaplasia and in two others it was secondary to intraepithelial corneoconjunctival neoplasia. Treatment reversed severe keratinization in a case of drug-induced pseudopemphigoid and stabilized the disease in one of the two affected eyes without additional treatment. In a case of ocular cicatricial pemphigoid, retinoic acid was useful as an adjuvant therapy to immunosuppression, by reversing keratinization of the conjunctiva. In two cases of corneoconjunctival neoplasia, lesions regressed markedly. Long-term treatment was well tolerated in three patients. Our findings suggest that retinoic acid ointment is effective in treating severe squamous metaplasia in cicatrizing diseases of the conjunctiva. Our findings indicate further that retinoic acid seems to inhibit growth of corneoconjunctival neoplasias and thus might be useful complementary therapy in this situation.
Keywords
Administration, Topical
Aged
Aged, 80 and over
Conjunctiva/*metabolism
Conjunctival Diseases/*drug therapy/pathology
Conjunctival Neoplasms/drug therapy
Conjunctivitis/drug therapy/pathology
Cornea/*metabolism
Corneal Diseases/*drug therapy/pathology
Epithelium/metabolism/pathology
Female
Humans
Keratins/*metabolism
Male
Metaplasia/drug therapy
Tretinoin/administration & dosage/*therapeutic use
Pubmed
Web of science
Create date
28/01/2008 14:09
Last modification date
20/08/2019 15:38