Topical retinoic acid in dysplastic and metaplastic keratinization of corneoconjunctival epithelium
Détails
ID Serval
serval:BIB_7CAEF3994365
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Topical retinoic acid in dysplastic and metaplastic keratinization of corneoconjunctival epithelium
Périodique
Graefe's Archive for Clinical and Experimental Ophthalmology
ISSN
0721-832X (Print)
Statut éditorial
Publié
Date de publication
1988
Volume
226
Numéro
1
Pages
22-6
Notes
Case Reports
Journal Article
Journal Article
Résumé
We report four cases of corneoconjunctival keratinization that were successfully treated with topical retinoic acid ointment. In two cases keratinization was due to squamous metaplasia and in two others it was secondary to intraepithelial corneoconjunctival neoplasia. Treatment reversed severe keratinization in a case of drug-induced pseudopemphigoid and stabilized the disease in one of the two affected eyes without additional treatment. In a case of ocular cicatricial pemphigoid, retinoic acid was useful as an adjuvant therapy to immunosuppression, by reversing keratinization of the conjunctiva. In two cases of corneoconjunctival neoplasia, lesions regressed markedly. Long-term treatment was well tolerated in three patients. Our findings suggest that retinoic acid ointment is effective in treating severe squamous metaplasia in cicatrizing diseases of the conjunctiva. Our findings indicate further that retinoic acid seems to inhibit growth of corneoconjunctival neoplasias and thus might be useful complementary therapy in this situation.
Mots-clé
Administration, Topical
Aged
Aged, 80 and over
Conjunctiva/*metabolism
Conjunctival Diseases/*drug therapy/pathology
Conjunctival Neoplasms/drug therapy
Conjunctivitis/drug therapy/pathology
Cornea/*metabolism
Corneal Diseases/*drug therapy/pathology
Epithelium/metabolism/pathology
Female
Humans
Keratins/*metabolism
Male
Metaplasia/drug therapy
Tretinoin/administration & dosage/*therapeutic use
Pubmed
Web of science
Création de la notice
28/01/2008 14:09
Dernière modification de la notice
20/08/2019 15:38