Structural covariance of superficial white matter in mild Alzheimer's disease compared to normal aging.

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Ressource 1Télécharger: BIB_7C6EF70D8DA7.P001.pdf (1645.72 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_7C6EF70D8DA7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Structural covariance of superficial white matter in mild Alzheimer's disease compared to normal aging.
Périodique
Brain and Behavior
Auteur(s)
Carmeli C., Fornari E., Jalili M., Meuli R., Knyazeva M.G.
ISSN
2162-3279 (Electronic)
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
4
Numéro
5
Pages
721-737
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Résumé
INTRODUCTION: Interindividual variations in regional structural properties covary across the brain, thus forming networks that change as a result of aging and accompanying neurological conditions. The alterations of superficial white matter (SWM) in Alzheimer's disease (AD) are of special interest, since they follow the AD-specific pattern characterized by the strongest neurodegeneration of the medial temporal lobe and association cortices.
METHODS: Here, we present an SWM network analysis in comparison with SWM topography based on the myelin content quantified with magnetization transfer ratio (MTR) for 39 areas in each hemisphere in 15 AD patients and 15 controls. The networks are represented by graphs, in which nodes correspond to the areas, and edges denote statistical associations between them.
RESULTS: In both groups, the networks were characterized by asymmetrically distributed edges (predominantly in the left hemisphere). The AD-related differences were also leftward. The edges lost due to AD tended to connect nodes in the temporal lobe to other lobes or nodes within or between the latter lobes. The newly gained edges were mostly confined to the temporal and paralimbic regions, which manifest demyelination of SWM already in mild AD.
CONCLUSION: This pattern suggests that the AD pathological process coordinates SWM demyelination in the temporal and paralimbic regions, but not elsewhere. A comparison of the MTR maps with MTR-based networks shows that although, in general, the changes in network architecture in AD recapitulate the topography of (de)myelination, some aspects of structural covariance (including the interhemispheric asymmetry of networks) have no immediate reflection in the myelination pattern.
Pubmed
Web of science
Open Access
Oui
Création de la notice
29/10/2014 12:02
Dernière modification de la notice
20/08/2019 14:38
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