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Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escape.
Malignant melanoma accounts for most of the increasing mortality from skin cancer. Melanoma cells were found to express Fas (also called Apo-1 or CD95) ligand (FasL). In metastatic lesions, Fas-expressing T cell infiltrates were proximal to FasL+ tumor cells. In vitro, apoptosis of Fas-sensitive target cells occurred upon incubation with melanoma tumor cells; and in vivo, injection of FasL+ mouse melanoma cells in mice led to rapid tumor formation. In contrast, tumorigenesis was delayed in Fas-deficient lpr mutant mice in which immune effector cells cannot be killed by FasL. Thus, FasL may contribute to the immune privilege of tumors.
Animals, Antigens, CD95/biosynthesis, Antigens, CD95/physiology, Apoptosis, Fas Ligand Protein, Humans, Ligands, Lymphocytes, Tumor-Infiltrating/cytology, Lymphocytes, Tumor-Infiltrating/immunology, Melanoma/immunology, Melanoma/metabolism, Membrane Glycoproteins/analysis, Membrane Glycoproteins/biosynthesis, Mice, Mice, Inbred C57BL, T-Lymphocytes, Cytotoxic/cytology, T-Lymphocytes, Cytotoxic/immunology, Tumor Cells, Cultured, Tumor Escape
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