Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escape.

Détails

ID Serval
serval:BIB_7B7255CAE951
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escape.
Périodique
Science
Auteur⸱e⸱s
Hahne M., Rimoldi D., Schröter M., Romero P., Schreier M., French L.E., Schneider P., Bornand T., Fontana A., Lienard D., Cerottini J., Tschopp J.
ISSN
0036-8075 (Print)
ISSN-L
0036-8075
Statut éditorial
Publié
Date de publication
1996
Volume
274
Numéro
5291
Pages
1363-1366
Langue
anglais
Résumé
Malignant melanoma accounts for most of the increasing mortality from skin cancer. Melanoma cells were found to express Fas (also called Apo-1 or CD95) ligand (FasL). In metastatic lesions, Fas-expressing T cell infiltrates were proximal to FasL+ tumor cells. In vitro, apoptosis of Fas-sensitive target cells occurred upon incubation with melanoma tumor cells; and in vivo, injection of FasL+ mouse melanoma cells in mice led to rapid tumor formation. In contrast, tumorigenesis was delayed in Fas-deficient lpr mutant mice in which immune effector cells cannot be killed by FasL. Thus, FasL may contribute to the immune privilege of tumors.
Mots-clé
Animals, Antigens, CD95/biosynthesis, Antigens, CD95/physiology, Apoptosis, Fas Ligand Protein, Humans, Ligands, Lymphocytes, Tumor-Infiltrating/cytology, Lymphocytes, Tumor-Infiltrating/immunology, Melanoma/immunology, Melanoma/metabolism, Membrane Glycoproteins/analysis, Membrane Glycoproteins/biosynthesis, Mice, Mice, Inbred C57BL, T-Lymphocytes, Cytotoxic/cytology, T-Lymphocytes, Cytotoxic/immunology, Tumor Cells, Cultured, Tumor Escape
Pubmed
Web of science
Création de la notice
28/01/2008 11:14
Dernière modification de la notice
20/08/2019 14:37
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