Article: article from journal or magazin.
Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome.
Cytoplasmic double-stranded DNA triggers cell death and secretion of the pro-inflammatory cytokine IL-1beta in macrophages. Recent reports now describe the mechanism underlying this observation. Upon sensing of DNA, the HIN-200 family member AIM2 triggers the assembly of the inflammasome, culminating in caspase-1 activation, IL-1beta maturation and pyroptotic cell death.
Antiviral Agents, Biosensing Techniques, Carrier Proteins/genetics, DNA/genetics, DNA-Binding Proteins/genetics, Humans, Immunity, Innate/genetics, Inflammation/genetics, Inflammation/immunology, Interferons/genetics, Interleukin-1beta/immunology, Nuclear Proteins/immunology
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