Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome.

Détails

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ID Serval
serval:BIB_7ACD5EDBDF55
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
UNIL/CHUV
Titre
Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome.
Périodique
Current biology
Auteur⸱e⸱s
Schroder K., Muruve D.A., Tschopp J.
ISSN
1879-0445[electronic]
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
19
Numéro
6
Pages
R262-R265
Langue
anglais
Résumé
Cytoplasmic double-stranded DNA triggers cell death and secretion of the pro-inflammatory cytokine IL-1beta in macrophages. Recent reports now describe the mechanism underlying this observation. Upon sensing of DNA, the HIN-200 family member AIM2 triggers the assembly of the inflammasome, culminating in caspase-1 activation, IL-1beta maturation and pyroptotic cell death.
Mots-clé
Antiviral Agents, Biosensing Techniques, Carrier Proteins/genetics, DNA/genetics, DNA-Binding Proteins/genetics, Humans, Immunity, Innate/genetics, Inflammation/genetics, Inflammation/immunology, Interferons/genetics, Interleukin-1beta/immunology, Nuclear Proteins/immunology
OAI-PMH
oai:serval.unil.ch:BIB_7ACD5EDBDF55
DOI
10.1016/j.cub.2009.02.011
Pubmed
19321146
Web of science
000264616200018
Open Access
Oui
Création de la notice
19/11/2009 15:54
Dernière modification de la notice
20/08/2019 15:36
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