Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome.

Schroder, K.; Muruve, D.A.; Tschopp, J.

doi:10.1016/j.cub.2009.02.011

Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome.

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Serval ID

serval:BIB_7ACD5EDBDF55

Type

Article: article from journal or magazin.

Publication sub-type

Editorial

Collection

Publications

Institution

UNIL/CHUV

Title

Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome.

Journal

Current biology

Author(s)

Schroder K., Muruve D.A., Tschopp J.

ISSN

1879-0445 (Electronic)

ISSN-L

0960-9822

Publication state

Published

Issued date

24/03/2009

Peer-reviewed

Oui

Volume

Number

Pages

R262-5

Language

english

Notes

Publication types: Journal Article
Publication Status: ppublish

Abstract

Cytoplasmic double-stranded DNA triggers cell death and secretion of the pro-inflammatory cytokine IL-1beta in macrophages. Recent reports now describe the mechanism underlying this observation. Upon sensing of DNA, the HIN-200 family member AIM2 triggers the assembly of the inflammasome, culminating in caspase-1 activation, IL-1beta maturation and pyroptotic cell death.

Keywords

Antiviral Agents, Biosensing Techniques, Carrier Proteins/genetics, DNA/genetics, DNA-Binding Proteins/genetics, Humans, Immunity, Innate/genetics, Inflammation/genetics, Inflammation/immunology, Interferons/genetics, Interleukin-1beta/immunology, NLR Family, Pyrin Domain-Containing 3 Protein, Nuclear Proteins/immunology, RNA-Binding Proteins

OAI-PMH

oai:serval.unil.ch:BIB_7ACD5EDBDF55

DOI

10.1016/j.cub.2009.02.011

Pubmed

19321146

Web of science

000264616200018

Open Access

Yes

Create date

19/11/2009 14:54