Immune suppression and skin cancer development: regulation by NKT cells

Details

Serval ID
serval:BIB_7972E8B137DC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Immune suppression and skin cancer development: regulation by NKT cells
Journal
Nature Immunology
Author(s)
Moodycliffe  A. M., Nghiem  D., Clydesdale  G., Ullrich  S. E.
ISSN
1529-2908 (Print)
Publication state
Published
Issued date
12/2000
Volume
1
Number
6
Pages
521-5
Notes
Journal Article
Research Support, U.S. Gov't, P.H.S. --- Old month value: Dec
Abstract
Ultraviolet (UV) radiation is carcinogenic and immunosuppressive. UV-induced immune suppression is mediated by antigen-specific T cells, which can transfer suppression to normal recipients. These cells are essential for controlling skin cancer development in the UV-irradiated host and in suppressing other immune responses, such as delayed-type hypersensitivity. Despite their importance in skin cancer development, their exact identity has remained elusive. We show here that natural killer T cells from UV-irradiated donor mice function as suppressor T cells and play a critical role in regulating the growth of UV-induced skin cancers and suppressing adaptive immune responses in vivo.
Keywords
Animals Antigens/administration & dosage Antigens, CD1/genetics/metabolism Female Hypersensitivity, Delayed Immune Tolerance Killer Cells, Natural/*immunology Mice Mice, Inbred C3H Mice, Inbred C57BL Mice, Knockout Neoplasms, Radiation-Induced/immunology Skin Neoplasms/*immunology Spleen/immunology T-Lymphocyte Subsets/*immunology Ultraviolet Rays/adverse effects
Pubmed
Web of science
Create date
25/01/2008 16:50
Last modification date
20/08/2019 14:35
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