Immune suppression and skin cancer development: regulation by NKT cells
Détails
ID Serval
serval:BIB_7972E8B137DC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Immune suppression and skin cancer development: regulation by NKT cells
Périodique
Nature Immunology
ISSN
1529-2908 (Print)
Statut éditorial
Publié
Date de publication
12/2000
Volume
1
Numéro
6
Pages
521-5
Notes
Journal Article
Research Support, U.S. Gov't, P.H.S. --- Old month value: Dec
Research Support, U.S. Gov't, P.H.S. --- Old month value: Dec
Résumé
Ultraviolet (UV) radiation is carcinogenic and immunosuppressive. UV-induced immune suppression is mediated by antigen-specific T cells, which can transfer suppression to normal recipients. These cells are essential for controlling skin cancer development in the UV-irradiated host and in suppressing other immune responses, such as delayed-type hypersensitivity. Despite their importance in skin cancer development, their exact identity has remained elusive. We show here that natural killer T cells from UV-irradiated donor mice function as suppressor T cells and play a critical role in regulating the growth of UV-induced skin cancers and suppressing adaptive immune responses in vivo.
Mots-clé
Animals
Antigens/administration & dosage
Antigens, CD1/genetics/metabolism
Female
Hypersensitivity, Delayed
Immune Tolerance
Killer Cells, Natural/*immunology
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Mice, Knockout
Neoplasms, Radiation-Induced/immunology
Skin Neoplasms/*immunology
Spleen/immunology
T-Lymphocyte Subsets/*immunology
Ultraviolet Rays/adverse effects
Pubmed
Web of science
Création de la notice
25/01/2008 17:50
Dernière modification de la notice
20/08/2019 15:35