Treatment of cytomegalovirus infection or disease in solid organ transplant recipients with valganciclovir.

Details

Serval ID
serval:BIB_78A1B0521279
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Treatment of cytomegalovirus infection or disease in solid organ transplant recipients with valganciclovir.
Journal
Transplantation Proceedings
Author(s)
Fellay J., Venetz J.P., Aubert J.D., Seydoux C., Pascual M., Meylan P.R.
ISSN
0041-1345
Publication state
Published
Issued date
2005
Peer-reviewed
Oui
Volume
37
Number
2
Pages
949-951
Language
english
Abstract
Valganciclovir (VGC) has proved efficacious and safe for the prophylaxis against cytomegalovirus (CMV) in high-risk transplant recipients and for the treatment of CMV retinitis in AIDS patients. We used VGC for the treatment of CMV infection (viremia without symptoms) or disease (CMV syndrome or tissue-invasive disease) in kidney, heart, and lung transplant recipients. Fourteen transplant recipients were treated: five for asymptomatic CMV infection and nine for CMV disease. VGC was administered in doses adjusted to renal function for 4 to 12 weeks (induction and maintenance therapy). Clinically, all nine patients with CMV disease responded to treatment. Microbiologically, treatment with VGC turned blood culture negative for CMV within 2 weeks in all patients and was associated with a > or =2 log decrease in blood CMV DNA within 3 weeks in 8 of 8 tested patients. With a follow-up of 6 months (n = 12 patients), asymptomatic recurrent CMV viremia was noted in five cases, and CMV syndrome noted in one case (all cases in the first 2 months after the end of treatment). VGC was clinically well tolerated in all patients; however, laboratory abnormalities occurred in three cases (mild increase in transaminases, thrombocytopenia, and pancytopenia). This preliminary experience strongly suggests that therapy with VGC is effective against CMV in organ transplant recipients; however, the exact duration of therapy remains to be determined: a longer course may be necessary to prevent early recurrence.
Keywords
Antiviral Agents, Cytomegalovirus Infections, Ganciclovir, Heart Transplantation, Humans, Immunosuppressive Agents, Kidney Transplantation, Lung Transplantation, Organ Transplantation
Pubmed
Web of science
Create date
29/01/2008 14:53
Last modification date
20/08/2019 15:35
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