Treatment of cytomegalovirus infection or disease in solid organ transplant recipients with valganciclovir.

Détails

ID Serval
serval:BIB_78A1B0521279
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Treatment of cytomegalovirus infection or disease in solid organ transplant recipients with valganciclovir.
Périodique
Transplantation Proceedings
Auteur(s)
Fellay J., Venetz J.P., Aubert J.D., Seydoux C., Pascual M., Meylan P.R.
ISSN
0041-1345
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
37
Numéro
2
Pages
949-951
Langue
anglais
Résumé
Valganciclovir (VGC) has proved efficacious and safe for the prophylaxis against cytomegalovirus (CMV) in high-risk transplant recipients and for the treatment of CMV retinitis in AIDS patients. We used VGC for the treatment of CMV infection (viremia without symptoms) or disease (CMV syndrome or tissue-invasive disease) in kidney, heart, and lung transplant recipients. Fourteen transplant recipients were treated: five for asymptomatic CMV infection and nine for CMV disease. VGC was administered in doses adjusted to renal function for 4 to 12 weeks (induction and maintenance therapy). Clinically, all nine patients with CMV disease responded to treatment. Microbiologically, treatment with VGC turned blood culture negative for CMV within 2 weeks in all patients and was associated with a > or =2 log decrease in blood CMV DNA within 3 weeks in 8 of 8 tested patients. With a follow-up of 6 months (n = 12 patients), asymptomatic recurrent CMV viremia was noted in five cases, and CMV syndrome noted in one case (all cases in the first 2 months after the end of treatment). VGC was clinically well tolerated in all patients; however, laboratory abnormalities occurred in three cases (mild increase in transaminases, thrombocytopenia, and pancytopenia). This preliminary experience strongly suggests that therapy with VGC is effective against CMV in organ transplant recipients; however, the exact duration of therapy remains to be determined: a longer course may be necessary to prevent early recurrence.
Mots-clé
Antiviral Agents, Cytomegalovirus Infections, Ganciclovir, Heart Transplantation, Humans, Immunosuppressive Agents, Kidney Transplantation, Lung Transplantation, Organ Transplantation
Pubmed
Web of science
Création de la notice
29/01/2008 13:53
Dernière modification de la notice
20/08/2019 14:35
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