Simple method for detection of MYH11 DNA rearrangements in patients with inv(16)(p13q22) and acute myeloid leukemia.

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Serval ID
serval:BIB_7898ADC0B96B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
UNIL/CHUV
Title
Simple method for detection of MYH11 DNA rearrangements in patients with inv(16)(p13q22) and acute myeloid leukemia.
Journal
Leukemia
Author(s)
van der Reijden B.A., Martinet D., Dauwerse J.G., Giles R.H., Wessels J.W., Beverstock G.C., Smit B., Mühlematter D., Jotterand Bellomo M., Gabert J., Lafage-Pochitaloff M., Reiffers J., Bilhou-Nabera C., van Ommen G.J., Hagemeijer A., Breuning M.H.
ISSN
0887-6924 (Print)
ISSN-L
0887-6924
Publication state
Published
Issued date
09/1996
Peer-reviewed
Oui
Volume
10
Number
9
Pages
1459-1462
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The pericentric inversion on chromosome 16 [inv(16)(p13q22)] and related t(16;16)(p13;q22) are recurrent aberrations associated with acute myeloid leukemia (AML) M4 Eo. Both abberations result in a fusion of the core binding factor beta (CBFB) and smooth muscle myosin heavy chain gene (MYH11). A selected genomic 6.9-kb BamHl probe detects MYH11 DNA rearrangements in 18 of 19 inv(16)/t(16;16) patients tested using HindIII digested DNA. The rearranged fragments were not detectable after remission in two cases tested, while they were present after relapse in one of these two cases tested.

Keywords
Chromosome Inversion, Chromosomes, Human, Pair 16, DNA, Neoplasm/genetics, Gene Rearrangement, Humans, Leukemia, Myelomonocytic, Acute/genetics, Myosin Heavy Chains/biosynthesis, Myosin Heavy Chains/genetics, Oncogene Proteins, Fusion/biosynthesis, Oncogene Proteins, Fusion/genetics, Translocation, Genetic
OAI-PMH
oai:serval.unil.ch:BIB_7898ADC0B96B
Pubmed
8751463
Web of science
A1996VF59800007
Create date
22/05/2009 9:15
Last modification date
20/08/2019 14:35
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