Simple method for detection of MYH11 DNA rearrangements in patients with inv(16)(p13q22) and acute myeloid leukemia.

Détails

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ID Serval
serval:BIB_7898ADC0B96B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
UNIL/CHUV
Titre
Simple method for detection of MYH11 DNA rearrangements in patients with inv(16)(p13q22) and acute myeloid leukemia.
Périodique
Leukemia
Auteur⸱e⸱s
van der Reijden B.A., Martinet D., Dauwerse J.G., Giles R.H., Wessels J.W., Beverstock G.C., Smit B., Mühlematter D., Jotterand Bellomo M., Gabert J., Lafage-Pochitaloff M., Reiffers J., Bilhou-Nabera C., van Ommen G.J., Hagemeijer A., Breuning M.H.
ISSN
0887-6924 (Print)
ISSN-L
0887-6924
Statut éditorial
Publié
Date de publication
09/1996
Peer-reviewed
Oui
Volume
10
Numéro
9
Pages
1459-1462
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The pericentric inversion on chromosome 16 [inv(16)(p13q22)] and related t(16;16)(p13;q22) are recurrent aberrations associated with acute myeloid leukemia (AML) M4 Eo. Both abberations result in a fusion of the core binding factor beta (CBFB) and smooth muscle myosin heavy chain gene (MYH11). A selected genomic 6.9-kb BamHl probe detects MYH11 DNA rearrangements in 18 of 19 inv(16)/t(16;16) patients tested using HindIII digested DNA. The rearranged fragments were not detectable after remission in two cases tested, while they were present after relapse in one of these two cases tested.

Mots-clé
Chromosome Inversion, Chromosomes, Human, Pair 16, DNA, Neoplasm/genetics, Gene Rearrangement, Humans, Leukemia, Myelomonocytic, Acute/genetics, Myosin Heavy Chains/biosynthesis, Myosin Heavy Chains/genetics, Oncogene Proteins, Fusion/biosynthesis, Oncogene Proteins, Fusion/genetics, Translocation, Genetic
OAI-PMH
oai:serval.unil.ch:BIB_7898ADC0B96B
Pubmed
8751463
Web of science
A1996VF59800007
Création de la notice
22/05/2009 10:15
Dernière modification de la notice
20/08/2019 15:35
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