Complex genetic patterns in human arise from a simple range-expansion model over continental landmasses.

Détails

Ressource 1Télécharger: journal.pone.0192460.pdf (1018.31 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_77ADA568BCF2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Complex genetic patterns in human arise from a simple range-expansion model over continental landmasses.
Périodique
PLoS One
Auteur(s)
Kanitz R., Guillot E.G., Antoniazza S., Neuenschwander S., Goudet J.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2018
Peer-reviewed
Oui
Volume
13
Numéro
2
Pages
e0192460
Langue
anglais
Résumé
Although it is generally accepted that geography is a major factor shaping human genetic differentiation, it is still disputed how much of this differentiation is a result of a simple process of isolation-by-distance, and if there are factors generating distinct clusters of genetic similarity. We address this question using a geographically explicit simulation framework coupled with an Approximate Bayesian Computation approach. Based on six simple summary statistics only, we estimated the most probable demographic parameters that shaped modern human evolution under an isolation by distance scenario, and found these were the following: an initial population in East Africa spread and grew from 4000 individuals to 5.7 million in about 132 000 years. Subsequent simulations with these estimates followed by cluster analyses produced results nearly identical to those obtained in real data. Thus, a simple diffusion model from East Africa explains a large portion of the genetic diversity patterns observed in modern humans. We argue that a model of isolation by distance along the continental landmasses might be the relevant null model to use when investigating selective effects in humans and probably many other species.

Mots-clé
General Biochemistry, Genetics and Molecular Biology, General Agricultural and Biological Sciences, General Medicine
Pubmed
Web of science
Open Access
Oui
Création de la notice
26/02/2018 10:00
Dernière modification de la notice
20/08/2019 15:34
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