Article: article from journal or magazin.
Therapeutic effects of bacteriophage Cpl-1 lysin against Streptococcus pneumoniae endocarditis in rats.
Antimicrobial Agents and Chemotherapy
Cpl-1, a pneumococcal phage lytic enzyme, was tested in rats with experimental endocarditis due to Streptococcus pneumoniae WB4. High-dose regimen Cpl-1 eliminated pneumococci from blood within 30 min and decreased bacterial titers in vegetations (>4 log10 CFU/g) within 2 h. Rapid bacterial lysis induced by Cpl-1 treatment increased cytokine secretion noticeably.
Animals, Cytokines/biosynthesis, Endocarditis, Bacterial/drug therapy, Endocarditis, Bacterial/microbiology, Enzymes/therapeutic use, Pneumococcal Infections/drug therapy, Pneumococcal Infections/microbiology, Rats
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