Therapeutic effects of bacteriophage Cpl-1 lysin against Streptococcus pneumoniae endocarditis in rats.

Détails

ID Serval
serval:BIB_7751028C2219
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Therapeutic effects of bacteriophage Cpl-1 lysin against Streptococcus pneumoniae endocarditis in rats.
Périodique
Antimicrobial Agents and Chemotherapy
Auteur(s)
Entenza J.M., Loeffler J.M., Grandgirard D., Fischetti V.A., Moreillon P.
ISSN
0066-4804[print], 0066-4804[linking]
Statut éditorial
Publié
Date de publication
2005
Volume
49
Numéro
11
Pages
4789-4792
Langue
anglais
Résumé
Cpl-1, a pneumococcal phage lytic enzyme, was tested in rats with experimental endocarditis due to Streptococcus pneumoniae WB4. High-dose regimen Cpl-1 eliminated pneumococci from blood within 30 min and decreased bacterial titers in vegetations (>4 log10 CFU/g) within 2 h. Rapid bacterial lysis induced by Cpl-1 treatment increased cytokine secretion noticeably.
Mots-clé
Animals, Cytokines/biosynthesis, Endocarditis, Bacterial/drug therapy, Endocarditis, Bacterial/microbiology, Enzymes/therapeutic use, Pneumococcal Infections/drug therapy, Pneumococcal Infections/microbiology, Rats
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 13:45
Dernière modification de la notice
20/08/2019 14:34
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