Therapeutic effects of bacteriophage Cpl-1 lysin against Streptococcus pneumoniae endocarditis in rats.
Details
Serval ID
serval:BIB_7751028C2219
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Therapeutic effects of bacteriophage Cpl-1 lysin against Streptococcus pneumoniae endocarditis in rats.
Journal
Antimicrobial Agents and Chemotherapy
ISSN
0066-4804[print], 0066-4804[linking]
Publication state
Published
Issued date
2005
Volume
49
Number
11
Pages
4789-4792
Language
english
Abstract
Cpl-1, a pneumococcal phage lytic enzyme, was tested in rats with experimental endocarditis due to Streptococcus pneumoniae WB4. High-dose regimen Cpl-1 eliminated pneumococci from blood within 30 min and decreased bacterial titers in vegetations (>4 log10 CFU/g) within 2 h. Rapid bacterial lysis induced by Cpl-1 treatment increased cytokine secretion noticeably.
Keywords
Animals, Cytokines/biosynthesis, Endocarditis, Bacterial/drug therapy, Endocarditis, Bacterial/microbiology, Enzymes/therapeutic use, Pneumococcal Infections/drug therapy, Pneumococcal Infections/microbiology, Rats
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 14:45
Last modification date
20/08/2019 15:34
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