Innate and adaptive effects of inflammasomes on T cell responses.

Détails

Ressource 1Télécharger: BIB_740A0D42CE97.P001.pdf (1991.93 [Ko])
Etat: Serval
Version: Author's accepted manuscript
ID Serval
serval:BIB_740A0D42CE97
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Innate and adaptive effects of inflammasomes on T cell responses.
Périodique
Current Opinion in Immunology
Auteur(s)
Dostert C., Ludigs K., Guarda G.
ISSN
1879-0372 (Electronic)
ISSN-L
0952-7915
Statut éditorial
Publié
Date de publication
2013
Volume
25
Numéro
3
Pages
359-365
Langue
anglais
Résumé
Inflammasomes are protein complexes that form in response to pathogen-derived or host-derived stress signals. Their activation leads to the production of inflammatory cytokines and promotes a pyrogenic cell death process. The massive release of inflammatory mediators that follows inflammasome activation is a key event in alarming innate immune cells. Growing evidence also highlights the role of inflammasome-dependent cytokines in shaping the adaptive immune response, as exemplified by the capacity of IL-1β to support Th17 responses, or by the finding that IL-18 evokes antigen-independent IFN-γ secretion by memory CD8(+) T cells. A deeper understanding of these mechanisms and on how to manipulate this powerful inflammatory system therefore represents an important step forward in the development of improved vaccine strategies.
Pubmed
Web of science
Création de la notice
13/12/2013 17:46
Dernière modification de la notice
03/03/2018 18:20
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