Selective accumulation of mature DC-Lamp+ dendritic cells in tumor sites is associated with efficient T-cell-mediated antitumor response and control of metastatic dissemination in melanoma.

Details

Serval ID
serval:BIB_73F6D15F6E16
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Selective accumulation of mature DC-Lamp+ dendritic cells in tumor sites is associated with efficient T-cell-mediated antitumor response and control of metastatic dissemination in melanoma.
Journal
Cancer Research
Author(s)
Movassagh M., Spatz A., Davoust J., Lebecque S., Romero P., Pittet M., Rimoldi D., Liénard D., Gugerli O., Ferradini L., Robert C., Avril M.F., Zitvogel L., Angevin E.
ISSN
0008-5472 (Print)
ISSN-L
0008-5472
Publication state
Published
Issued date
2004
Volume
64
Number
6
Pages
2192-2198
Language
english
Abstract
The clinical relevance of dendritic cells (DCs) at the tumor site remains a matter of debate concerning their role in the generation of effective antitumor immunity in human cancers. We performed a comprehensive immunohistochemical analysis using a panel of DC-specific antibodies on regressing tumor lesions and sentinel lymph nodes (SLNs) in melanoma patients. Here we show in a case report involving spontaneous regression of metastatic melanoma that the accumulation of DC-Lamp+ DCs, clustered with tumor cells and lymphocytes, is associated with local expansion of antigen-specific memory effector CTLs. These findings were extended in a series of 19 melanoma-positive SLNs and demonstrated a significant correlation between the density of DC-Lamp+ DC infiltrates in SLNs with the absence of metastasis in downstream lymph nodes. This study, albeit performed in a limited series of patients, points to a pivotal role of mature DCs in the local expansion of efficient antitumor T-cell-mediated immune responses at the initial sites of metastasis and may have important implications regarding the prognosis, staging, and immunotherapy of melanoma patients.
Keywords
Adult, Antigens, CD/immunology, Antigens, Neoplasm, Dendritic Cells/immunology, Humans, Immunophenotyping, Ligands, Lymph Nodes/pathology, Lymphatic Metastasis, Lymphocytes, Tumor-Infiltrating, Lysosome-Associated Membrane Glycoproteins, MART-1 Antigen, Male, Melanoma/immunology, Melanoma/secondary, Neoplasm Proteins/metabolism, Receptors, CCR6, Receptors, CCR7, Receptors, Chemokine/metabolism, Sentinel Lymph Node Biopsy, Skin Neoplasms/immunology, Skin Neoplasms/pathology, T-Lymphocytes, Cytotoxic/immunology
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 11:27
Last modification date
20/08/2019 14:31
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