Selective accumulation of mature DC-Lamp+ dendritic cells in tumor sites is associated with efficient T-cell-mediated antitumor response and control of metastatic dissemination in melanoma.

Détails

ID Serval
serval:BIB_73F6D15F6E16
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Selective accumulation of mature DC-Lamp+ dendritic cells in tumor sites is associated with efficient T-cell-mediated antitumor response and control of metastatic dissemination in melanoma.
Périodique
Cancer Research
Auteur(s)
Movassagh M., Spatz A., Davoust J., Lebecque S., Romero P., Pittet M., Rimoldi D., Liénard D., Gugerli O., Ferradini L., Robert C., Avril M.F., Zitvogel L., Angevin E.
ISSN
0008-5472 (Print)
ISSN-L
0008-5472
Statut éditorial
Publié
Date de publication
2004
Volume
64
Numéro
6
Pages
2192-2198
Langue
anglais
Résumé
The clinical relevance of dendritic cells (DCs) at the tumor site remains a matter of debate concerning their role in the generation of effective antitumor immunity in human cancers. We performed a comprehensive immunohistochemical analysis using a panel of DC-specific antibodies on regressing tumor lesions and sentinel lymph nodes (SLNs) in melanoma patients. Here we show in a case report involving spontaneous regression of metastatic melanoma that the accumulation of DC-Lamp+ DCs, clustered with tumor cells and lymphocytes, is associated with local expansion of antigen-specific memory effector CTLs. These findings were extended in a series of 19 melanoma-positive SLNs and demonstrated a significant correlation between the density of DC-Lamp+ DC infiltrates in SLNs with the absence of metastasis in downstream lymph nodes. This study, albeit performed in a limited series of patients, points to a pivotal role of mature DCs in the local expansion of efficient antitumor T-cell-mediated immune responses at the initial sites of metastasis and may have important implications regarding the prognosis, staging, and immunotherapy of melanoma patients.
Mots-clé
Adult, Antigens, CD/immunology, Antigens, Neoplasm, Dendritic Cells/immunology, Humans, Immunophenotyping, Ligands, Lymph Nodes/pathology, Lymphatic Metastasis, Lymphocytes, Tumor-Infiltrating, Lysosome-Associated Membrane Glycoproteins, MART-1 Antigen, Male, Melanoma/immunology, Melanoma/secondary, Neoplasm Proteins/metabolism, Receptors, CCR6, Receptors, CCR7, Receptors, Chemokine/metabolism, Sentinel Lymph Node Biopsy, Skin Neoplasms/immunology, Skin Neoplasms/pathology, T-Lymphocytes, Cytotoxic/immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 11:27
Dernière modification de la notice
20/08/2019 14:31
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