The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Descriptive Review of Tubercular Uveitis in Paediatric Population.

Details

Serval ID
serval:BIB_6E987901C2DD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Descriptive Review of Tubercular Uveitis in Paediatric Population.
Journal
Ocular immunology and inflammation
Author(s)
Testi I., Agrawal R., Mahajan S., Agarwal A., Gunasekeran D.V., Raje D., Aggarwal K., Murthy S.I., Westcott M., Chee S.P., Mccluskey P., Ho S.L., Teoh S., Cimino L., Biswas J., Narain S., Agarwal M., Mahendradas P., Khairallah M., Jones N., Tugal-Tutkun I., Babu K., Basu S., Carreño E., Lee R., Al-Dhibi H., Bodaghi B., Invernizzi A., Goldstein D.A., Herbort C.P., Barisani-Asenbauer T., González-López J.J., Androudi S., Bansal R., Moharana B., Esposti S.D., Tasiopoulou A., Nadarajah S., Agarwal M., Abraham S., Vala R., Singh R., Sharma A., Sharma K., Zierhut M., Kon O.M., Cunningham E.T., Kempen J.H., Nguyen Q.D., Pavesio C., Gupta V.
ISSN
1744-5078 (Electronic)
ISSN-L
0927-3948
Publication state
Published
Issued date
30/09/2020
Peer-reviewed
Oui
Volume
28
Number
sup1
Pages
58-64
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Purpose: To examine disease profile of tubercular uveitis (TBU) in Paediatric population.Methods: Among 945 patients of the retrospective multinational study by the Collaborative Ocular Tuberculosis Study (COTS)-1, 29 Paediatric patients diagnosed with TBU were analyzed.Results: Mean age of disease presentation was 12.8 (range 4-18 years), with predominance of males (n = 14/20; 70.0%) and Asian ethnicity (n = 25/29; 86.2%). Posterior uveitis (n = 14/28; 50%) was the most frequent uveitis phenotype, with choroidal involvement occurring in 64.7% (n = 11/17). Incidence of optic disc edema and macular edema was higher in children (n = 8/18; 44.4% and n = 5/18; 27.8%, respectively) than in adults (n = 160/942; 16.9% and n = 135/942; 14.3%, respectively). Comparison of optic disc edema between subgroups showed a significant difference (P =.006). All patients received oral corticosteroids, most of them with antitubercular therapy. Treatment failure developed in 4.8% (n = 1/21).Conclusions: Children have a more severe inflammatory response to the disease, and an intensive anti-inflammatory therapeutic regimen is required to achieve a positive treatment outcome.
Keywords
Collaborative Ocular Tuberculosis Study (COTS), Ocular tuberculosis, children, pediatric population, tubercular uveitis
Pubmed
Web of science
Create date
28/08/2020 7:51
Last modification date
20/12/2023 7:14
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