The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Descriptive Review of Tubercular Uveitis in Paediatric Population.

Détails

ID Serval
serval:BIB_6E987901C2DD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Descriptive Review of Tubercular Uveitis in Paediatric Population.
Périodique
Ocular immunology and inflammation
Auteur⸱e⸱s
Testi I., Agrawal R., Mahajan S., Agarwal A., Gunasekeran D.V., Raje D., Aggarwal K., Murthy S.I., Westcott M., Chee S.P., Mccluskey P., Ho S.L., Teoh S., Cimino L., Biswas J., Narain S., Agarwal M., Mahendradas P., Khairallah M., Jones N., Tugal-Tutkun I., Babu K., Basu S., Carreño E., Lee R., Al-Dhibi H., Bodaghi B., Invernizzi A., Goldstein D.A., Herbort C.P., Barisani-Asenbauer T., González-López J.J., Androudi S., Bansal R., Moharana B., Esposti S.D., Tasiopoulou A., Nadarajah S., Agarwal M., Abraham S., Vala R., Singh R., Sharma A., Sharma K., Zierhut M., Kon O.M., Cunningham E.T., Kempen J.H., Nguyen Q.D., Pavesio C., Gupta V.
ISSN
1744-5078 (Electronic)
ISSN-L
0927-3948
Statut éditorial
Publié
Date de publication
30/09/2020
Peer-reviewed
Oui
Volume
28
Numéro
sup1
Pages
58-64
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Purpose: To examine disease profile of tubercular uveitis (TBU) in Paediatric population.Methods: Among 945 patients of the retrospective multinational study by the Collaborative Ocular Tuberculosis Study (COTS)-1, 29 Paediatric patients diagnosed with TBU were analyzed.Results: Mean age of disease presentation was 12.8 (range 4-18 years), with predominance of males (n = 14/20; 70.0%) and Asian ethnicity (n = 25/29; 86.2%). Posterior uveitis (n = 14/28; 50%) was the most frequent uveitis phenotype, with choroidal involvement occurring in 64.7% (n = 11/17). Incidence of optic disc edema and macular edema was higher in children (n = 8/18; 44.4% and n = 5/18; 27.8%, respectively) than in adults (n = 160/942; 16.9% and n = 135/942; 14.3%, respectively). Comparison of optic disc edema between subgroups showed a significant difference (P =.006). All patients received oral corticosteroids, most of them with antitubercular therapy. Treatment failure developed in 4.8% (n = 1/21).Conclusions: Children have a more severe inflammatory response to the disease, and an intensive anti-inflammatory therapeutic regimen is required to achieve a positive treatment outcome.
Mots-clé
Collaborative Ocular Tuberculosis Study (COTS), Ocular tuberculosis, children, pediatric population, tubercular uveitis
Pubmed
Web of science
Création de la notice
28/08/2020 8:51
Dernière modification de la notice
20/12/2023 8:14
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