Article: article from journal or magazin.
Selective suppression of cytokine secretion in whole blood cell cultures of patients with colorectal cancer.
British journal of cancer
Publication types: Journal Article - Publication Status: ppublish
We have investigated the secretion of interferon alpha (IFN-alpha), IFN-gamma, interleukin-1alpha (IL-1alpha), IL-1beta, IL-2 and tumour necrosis factor alpha (TNF-alpha) in whole blood cell cultures (WBCCs) of colorectal cancer patients upon mitogen stimulation. Whereas the values for IL-1beta and TNF-alpha remained virtually unchanged in comparison with healthy control subjects, WBCCs of colorectal cancer patients secreted significantly lower amounts of IFN-alpha (P < 0.005), IFN-gamma (P < 0.0001), IL-1alpha (P < 0.0001) and IL-2 (P < 0.05). This reduction correlated with the progression of the disease. The total leucocyte and monocyte population were almost identical in both groups. In contrast, a dramatic depletion of lymphocytes was observed in colorectal cancer patients, which affected both lymphocyte counts (P < 0.0005) and their distribution (P < 0.0001). Our results suggest a selective suppression of cytokines in colorectal cancer patients that is related to tumour burden. Several mechanisms might account for this phenomenon, one of which might be lymphocyte depletion.
Adult, Aged, Cells, Cultured, Colorectal Neoplasms, Cytokines, Disease Progression, Female, Humans, Interferon-alpha, Interferon-gamma, Interleukin-1, Interleukin-2, Leukocyte Count, Leukocytes, Lymphocyte Count, Male, Middle Aged, Monocytes, Phytohemagglutinins, Tumor Necrosis Factor-alpha
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