Selective suppression of cytokine secretion in whole blood cell cultures of patients with colorectal cancer.

Détails

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Etat: Public
Version: Final published version
Licence: Non spécifiée
ID Serval
serval:BIB_6CCA32411D95
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Selective suppression of cytokine secretion in whole blood cell cultures of patients with colorectal cancer.
Périodique
British journal of cancer
Auteur(s)
Lahm H., Schindel M., Frikart L., Cerottini J.P., Yilmaz A., Givel J.C., Fischer J.R.
ISSN
0007-0920
Statut éditorial
Publié
Date de publication
1998
Peer-reviewed
Oui
Volume
78
Numéro
8
Pages
1018-23
Langue
anglais
Notes
Publication types: Journal Article - Publication Status: ppublish
Résumé
We have investigated the secretion of interferon alpha (IFN-alpha), IFN-gamma, interleukin-1alpha (IL-1alpha), IL-1beta, IL-2 and tumour necrosis factor alpha (TNF-alpha) in whole blood cell cultures (WBCCs) of colorectal cancer patients upon mitogen stimulation. Whereas the values for IL-1beta and TNF-alpha remained virtually unchanged in comparison with healthy control subjects, WBCCs of colorectal cancer patients secreted significantly lower amounts of IFN-alpha (P < 0.005), IFN-gamma (P < 0.0001), IL-1alpha (P < 0.0001) and IL-2 (P < 0.05). This reduction correlated with the progression of the disease. The total leucocyte and monocyte population were almost identical in both groups. In contrast, a dramatic depletion of lymphocytes was observed in colorectal cancer patients, which affected both lymphocyte counts (P < 0.0005) and their distribution (P < 0.0001). Our results suggest a selective suppression of cytokines in colorectal cancer patients that is related to tumour burden. Several mechanisms might account for this phenomenon, one of which might be lymphocyte depletion.
Mots-clé
Adult, Aged, Cells, Cultured, Colorectal Neoplasms, Cytokines, Disease Progression, Female, Humans, Interferon-alpha, Interferon-gamma, Interleukin-1, Interleukin-2, Leukocyte Count, Leukocytes, Lymphocyte Count, Male, Middle Aged, Monocytes, Phytohemagglutinins, Tumor Necrosis Factor-alpha
Pubmed
Web of science
Création de la notice
28/01/2008 8:56
Dernière modification de la notice
20/08/2019 14:26
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