Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Rhumatologie. La patiente polyarthritique qui ne répond pas a l'anti-TNF. [Rhumatology. The rheumatoid arthritis patient who does not respond to anti-TNF]
Revue Médicale Suisse
English Abstract Journal Article Review --- Old month value: Jan 10
Anti-TNF treatments have given patients with rheumatoid arthritis considerable hope and relief. However, 20-30% of patients do not respond sufficiently to a given anti-TNF drug. In this situation, current strategies include switching to an alternative agent, increasing the dose of the current agent or to return to conventional DMARDs. The arrival of new biologics, which target different molecules than TNF, opens the perspective to other pathways of immunomodulation in RA. These drugs include rituximab (anti-CD20), abatacept (CTLA4Ig) and tocilizumab (anti- IL6R). Comparative studies are urgently needed to assess the efficacy of the different treatment options in order to provide the best therapeutic strategy for our patients.
Arthritis, Rheumatoid/*drug therapy Humans Treatment Failure Tumor Necrosis Factors/*antagonists & inhibitors
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