Rhumatologie. La patiente polyarthritique qui ne répond pas a l'anti-TNF. [Rhumatology. The rheumatoid arthritis patient who does not respond to anti-TNF]
Details
Serval ID
serval:BIB_6CB7E8809268
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Rhumatologie. La patiente polyarthritique qui ne répond pas a l'anti-TNF. [Rhumatology. The rheumatoid arthritis patient who does not respond to anti-TNF]
Journal
Revue Médicale Suisse
ISSN
1660-9379 (Print)
Publication state
Published
Issued date
01/2007
Volume
3
Number
93
Pages
60-2
Notes
English Abstract Journal Article Review --- Old month value: Jan 10
Abstract
Anti-TNF treatments have given patients with rheumatoid arthritis considerable hope and relief. However, 20-30% of patients do not respond sufficiently to a given anti-TNF drug. In this situation, current strategies include switching to an alternative agent, increasing the dose of the current agent or to return to conventional DMARDs. The arrival of new biologics, which target different molecules than TNF, opens the perspective to other pathways of immunomodulation in RA. These drugs include rituximab (anti-CD20), abatacept (CTLA4Ig) and tocilizumab (anti- IL6R). Comparative studies are urgently needed to assess the efficacy of the different treatment options in order to provide the best therapeutic strategy for our patients.
Keywords
Arthritis, Rheumatoid/*drug therapy Humans Treatment Failure Tumor Necrosis Factors/*antagonists & inhibitors
Pubmed
Create date
25/01/2008 9:38
Last modification date
20/08/2019 15:26
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