Rhumatologie. La patiente polyarthritique qui ne répond pas a l'anti-TNF. [Rhumatology. The rheumatoid arthritis patient who does not respond to anti-TNF]
Détails
ID Serval
serval:BIB_6CB7E8809268
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Rhumatologie. La patiente polyarthritique qui ne répond pas a l'anti-TNF. [Rhumatology. The rheumatoid arthritis patient who does not respond to anti-TNF]
Périodique
Revue Médicale Suisse
ISSN
1660-9379 (Print)
Statut éditorial
Publié
Date de publication
01/2007
Volume
3
Numéro
93
Pages
60-2
Notes
English Abstract Journal Article Review --- Old month value: Jan 10
Résumé
Anti-TNF treatments have given patients with rheumatoid arthritis considerable hope and relief. However, 20-30% of patients do not respond sufficiently to a given anti-TNF drug. In this situation, current strategies include switching to an alternative agent, increasing the dose of the current agent or to return to conventional DMARDs. The arrival of new biologics, which target different molecules than TNF, opens the perspective to other pathways of immunomodulation in RA. These drugs include rituximab (anti-CD20), abatacept (CTLA4Ig) and tocilizumab (anti- IL6R). Comparative studies are urgently needed to assess the efficacy of the different treatment options in order to provide the best therapeutic strategy for our patients.
Mots-clé
Arthritis, Rheumatoid/*drug therapy Humans Treatment Failure Tumor Necrosis Factors/*antagonists & inhibitors
Pubmed
Création de la notice
25/01/2008 8:38
Dernière modification de la notice
20/08/2019 14:26
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