Wound repair and regeneration.

Details

Serval ID
serval:BIB_6B7F2E366441
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Wound repair and regeneration.
Journal
Nature
Author(s)
Gurtner G.C., Werner S., Barrandon Y., Longaker M.T.
ISSN
1476-4687
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
453
Number
7193
Pages
314-321
Language
english
Abstract
The repair of wounds is one of the most complex biological processes that occur during human life. After an injury, multiple biological pathways immediately become activated and are synchronized to respond. In human adults, the wound repair process commonly leads to a non-functioning mass of fibrotic tissue known as a scar. By contrast, early in gestation, injured fetal tissues can be completely recreated, without fibrosis, in a process resembling regeneration. Some organisms, however, retain the ability to regenerate tissue throughout adult life. Knowledge gained from studying such organisms might help to unlock latent regenerative pathways in humans, which would change medical practice as much as the introduction of antibiotics did in the twentieth century.
Keywords
Animals, Fibrosis, Humans, Intercellular Signaling Peptides and Proteins, Regeneration, Regenerative Medicine, Stem Cells, Wound Healing
Pubmed
Web of science
Create date
25/02/2009 10:45
Last modification date
20/08/2019 15:25
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