Article: article from journal or magazin.
Remarkable anticancer activity of triruthenium-arene clusters compared to tetraruthenium-arene clusters
Journal of Cluster Science
The in vitro activity of a series of ruthenium clusters, [(eta(6)-C6H6)(eta(6)-C6Me6)(2)Ru-3(mu-H)(3)(mu(3)-O)][BF4], [(eta(6)-C6H6)(eta(6)-1,4-(PrC6H4Me)-Pr-i)(eta(6)-C6Me6)Ru-3(mu-H)(3)(mu (3)-O)][BF4], [(eta(6)-C6H6)(4)Ru-4(mu-H)(4)][BF4](2), [(eta(6)-C6H5Me)(4)Ru-4(mu-H)(4)][BF4](2) and [(eta(6)-C6H6)(4)Ru-4(mu-H)(3)(mu-OH)][Cl](2), has been evaluated against A2780 and A2780cisR ovarian carcinoma cell lines. Both triruthenium clusters are very active compared to ruthenium compounds in general, whereas the tetraruthenium clusters do not display significant cytotoxicities. Since the triruthenium clusters are known to form supramolecular interactions with arenes and other functions, it is possible that such interactions are also important with respect to their mode of biological activity. The X-ray structure analysis of [(eta(6)-C6H5Me)(4)Ru-4(mu-H)(4)][PF6](2) is also reported
ANALOGS/analysis/anticancer drugs/ANTITUMOR DRUGS/AQUEOUS-SOLUTION/bioinorganic chemistry/BIOORGANOMETALLIC CHEMISTRY/BUILDUP/Carcinoma/CATALYTIC-PROPERTIES/CATION/Cell Line/chemistry/clusters/CYTOTOXICITY/in vitro assays/IN-VITRO/IN-VITRO EVALUATION/medicinal chemistry/PTA COMPLEXES/Ruthenium/Switzerland/TRINUCLEAR
Web of science
Last modification date