Remarkable anticancer activity of triruthenium-arene clusters compared to tetraruthenium-arene clusters

Détails

ID Serval
serval:BIB_6B40C49C1B7A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Remarkable anticancer activity of triruthenium-arene clusters compared to tetraruthenium-arene clusters
Périodique
Journal of Cluster Science
Auteur⸱e⸱s
Therrien  B., Ang  W. H., Cherioux  F., Vieille-Petit  L., Juillerat-Jeanneret  L., Suss-Fink  G., Dyson  P. J.
ISSN
1040-7278
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
18
Numéro
3
Pages
741-752
Résumé
The in vitro activity of a series of ruthenium clusters, [(eta(6)-C6H6)(eta(6)-C6Me6)(2)Ru-3(mu-H)(3)(mu(3)-O)][BF4], [(eta(6)-C6H6)(eta(6)-1,4-(PrC6H4Me)-Pr-i)(eta(6)-C6Me6)Ru-3(mu-H)(3)(mu (3)-O)][BF4], [(eta(6)-C6H6)(4)Ru-4(mu-H)(4)][BF4](2), [(eta(6)-C6H5Me)(4)Ru-4(mu-H)(4)][BF4](2) and [(eta(6)-C6H6)(4)Ru-4(mu-H)(3)(mu-OH)][Cl](2), has been evaluated against A2780 and A2780cisR ovarian carcinoma cell lines. Both triruthenium clusters are very active compared to ruthenium compounds in general, whereas the tetraruthenium clusters do not display significant cytotoxicities. Since the triruthenium clusters are known to form supramolecular interactions with arenes and other functions, it is possible that such interactions are also important with respect to their mode of biological activity. The X-ray structure analysis of [(eta(6)-C6H5Me)(4)Ru-4(mu-H)(4)][PF6](2) is also reported
Mots-clé
ANALOGS/analysis/anticancer drugs/ANTITUMOR DRUGS/AQUEOUS-SOLUTION/bioinorganic chemistry/BIOORGANOMETALLIC CHEMISTRY/BUILDUP/Carcinoma/CATALYTIC-PROPERTIES/CATION/Cell Line/chemistry/clusters/CYTOTOXICITY/in vitro assays/IN-VITRO/IN-VITRO EVALUATION/medicinal chemistry/PTA COMPLEXES/Ruthenium/Switzerland/TRINUCLEAR
Web of science
Création de la notice
30/01/2008 19:10
Dernière modification de la notice
20/08/2019 15:25
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