Article: article from journal or magazin.
The tripartite motif family identifies cell compartments.
A functional genomic approach, based on systematic data gathering, was used to characterize a family of proteins containing a tripartite motif (TRIM). A total of 37 TRIM genes/proteins were studied, 21 of which were novel. The results demonstrate that TRIM proteins share a common function: by means of homo-multimerization they identify specific cell compartments.
Amino Acid Motifs/physiology, Animals, Blotting, Northern, Carrier Proteins, Cell Compartmentation/physiology, Cell Line, Chromosome Mapping, Cloning, Molecular, Databases, Factual, Embryo, Mammalian, Humans, In Situ Hybridization, Mice, Molecular Sequence Data, Multigene Family/genetics, Mutagenesis, Site-Directed, Nerve Tissue Proteins, Organ Specificity, Protein Binding/physiology, Protein Structure, Tertiary/physiology, Proteins/physiology, Sequence Homology, Amino Acid, Subcellular Fractions/metabolism, Two-Hybrid System Techniques
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