The tripartite motif family identifies cell compartments.

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Serval ID
serval:BIB_6A96E2C992E0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Production externe
Title
The tripartite motif family identifies cell compartments.
Journal
EMBO Journal
Author(s)
Reymond A., Meroni G., Fantozzi A., Merla G., Cairo S., Luzi L., Riganelli D., Zanaria E., Messali S., Cainarca S., Guffanti A., Minucci S., Pelicci P.G., Ballabio A.
ISSN
0261-4189 (Print)
ISSN-L
0261-4189
Publication state
Published
Issued date
2001
Volume
20
Number
9
Pages
2140-2151
Language
english
Abstract
A functional genomic approach, based on systematic data gathering, was used to characterize a family of proteins containing a tripartite motif (TRIM). A total of 37 TRIM genes/proteins were studied, 21 of which were novel. The results demonstrate that TRIM proteins share a common function: by means of homo-multimerization they identify specific cell compartments.
Keywords
Amino Acid Motifs/physiology, Animals, Blotting, Northern, Carrier Proteins, Cell Compartmentation/physiology, Cell Line, Chromosome Mapping, Cloning, Molecular, Databases, Factual, Embryo, Mammalian, Humans, In Situ Hybridization, Mice, Molecular Sequence Data, Multigene Family/genetics, Mutagenesis, Site-Directed, Nerve Tissue Proteins, Organ Specificity, Protein Binding/physiology, Protein Structure, Tertiary/physiology, Proteins/physiology, Sequence Homology, Amino Acid, Subcellular Fractions/metabolism, Two-Hybrid System Techniques
DOI
10.1093/emboj/20.9.2140
Pubmed
11331580
Web of science
000168597600004
Open Access
Yes
Create date
24/01/2008 15:52
Last modification date
20/08/2019 14:25
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