Intrathymic deletion of self-reactive cells prevented by neonatal anti-CD4 antibody treatment

Details

Serval ID
serval:BIB_696F75841081
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Intrathymic deletion of self-reactive cells prevented by neonatal anti-CD4 antibody treatment
Journal
Nature
Author(s)
MacDonald  H. R., Hengartner  H., Pedrazzini  T.
ISSN
0028-0836 (Print)
Publication state
Published
Issued date
09/1988
Volume
335
Number
6186
Pages
174-6
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep 8
Abstract
T-cell differentiation in the thymus involves the coordinate expression of genes encoding the alpha and beta chains of the major histocompatibility complex-restricted heterodimeric antigen receptor (TCR) complex, as well as other functionally important molecules such as CD4 and CD8. The repertoire of TCR expressed by T cells is generally thought to be influenced by positive and/or negative selection events occurring when TCRs on developing T cells interact with self-antigens and major histocompatibility complex components. Using a model system in which specific antigen-reactive cells can be monitored by virtue of their preferential expression of certain TCR beta-chain variable (V beta) domains, it has been shown that self-reactive T cells are clonally deleted during development. We report here that clonal deletion of V+ beta 6 cells in Mlsa mice can be prevented by in vivo neonatal administration of monoclonal antibodies directed against CD4. Furthermore, as anti-CD4 monoclonal antibody treatment resulted in the reappearance of V+ beta 6 cells in the mature CD8+ T-cell subset, it is likely that clonal deletion acts on the CD4+CD8+ thymocyte subset and that this subset is an intermediate stage in the differentiation pathway of both CD4+ and CD8+ T-cell lineages.
Keywords
Animals Antibodies, Monoclonal Antigens, Differentiation, T-Lymphocyte/*immunology Cell Differentiation Mice Mice, Inbred BALB C Minor Histocompatibility Loci Receptors, Antigen, T-Cell/immunology T-Lymphocytes, Helper-Inducer/*cytology T-Lymphocytes, Regulatory/cytology Thymus Gland/*cytology
Pubmed
Web of science
Create date
25/01/2008 8:45
Last modification date
20/08/2019 14:24
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