Intrathymic deletion of self-reactive cells prevented by neonatal anti-CD4 antibody treatment
Détails
ID Serval
serval:BIB_696F75841081
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Intrathymic deletion of self-reactive cells prevented by neonatal anti-CD4 antibody treatment
Périodique
Nature
ISSN
0028-0836 (Print)
Statut éditorial
Publié
Date de publication
09/1988
Volume
335
Numéro
6186
Pages
174-6
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep 8
Research Support, Non-U.S. Gov't --- Old month value: Sep 8
Résumé
T-cell differentiation in the thymus involves the coordinate expression of genes encoding the alpha and beta chains of the major histocompatibility complex-restricted heterodimeric antigen receptor (TCR) complex, as well as other functionally important molecules such as CD4 and CD8. The repertoire of TCR expressed by T cells is generally thought to be influenced by positive and/or negative selection events occurring when TCRs on developing T cells interact with self-antigens and major histocompatibility complex components. Using a model system in which specific antigen-reactive cells can be monitored by virtue of their preferential expression of certain TCR beta-chain variable (V beta) domains, it has been shown that self-reactive T cells are clonally deleted during development. We report here that clonal deletion of V+ beta 6 cells in Mlsa mice can be prevented by in vivo neonatal administration of monoclonal antibodies directed against CD4. Furthermore, as anti-CD4 monoclonal antibody treatment resulted in the reappearance of V+ beta 6 cells in the mature CD8+ T-cell subset, it is likely that clonal deletion acts on the CD4+CD8+ thymocyte subset and that this subset is an intermediate stage in the differentiation pathway of both CD4+ and CD8+ T-cell lineages.
Mots-clé
Animals
Antibodies, Monoclonal
Antigens, Differentiation, T-Lymphocyte/*immunology
Cell Differentiation
Mice
Mice, Inbred BALB C
Minor Histocompatibility Loci
Receptors, Antigen, T-Cell/immunology
T-Lymphocytes, Helper-Inducer/*cytology
T-Lymphocytes, Regulatory/cytology
Thymus Gland/*cytology
Pubmed
Web of science
Création de la notice
25/01/2008 9:45
Dernière modification de la notice
20/08/2019 15:24