RocS drives chromosome segregation and nucleoid protection in Streptococcus pneumoniae.

Détails

ID Serval
serval:BIB_66E1D434E25B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
RocS drives chromosome segregation and nucleoid protection in Streptococcus pneumoniae.
Périodique
Nature microbiology
Auteur(s)
Mercy C., Ducret A., Slager J., Lavergne J.P., Freton C., Nagarajan S.N., Garcia P.S., Noirot-Gros M.F., Dubarry N., Nourikyan J., Veening J.W., Grangeasse C.
ISSN
2058-5276 (Electronic)
ISSN-L
2058-5276
Statut éditorial
Publié
Date de publication
10/2019
Peer-reviewed
Oui
Volume
4
Numéro
10
Pages
1661-1670
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Chromosome segregation in bacteria is poorly understood outside some prominent model strains <sup>1-5</sup> and even less is known about how it is coordinated with other cellular processes. This is the case for the opportunistic human pathogen Streptococcus pneumoniae (the pneumococcus) <sup>6</sup> , which lacks the Min and the nucleoid occlusion systems <sup>7</sup> , and possesses only an incomplete chromosome partitioning Par(A)BS system, in which ParA is absent <sup>8</sup> . The bacterial tyrosine kinase <sup>9</sup> CpsD, which is required for capsule production, was previously found to interfere with chromosome segregation <sup>10</sup> . Here, we identify a protein of unknown function that interacts with CpsD and drives chromosome segregation. RocS (Regulator of Chromosome Segregation) is a membrane-bound protein that interacts with both DNA and the chromosome partitioning protein ParB to properly segregate the origin of replication region to new daughter cells. In addition, we show that RocS interacts with the cell division protein FtsZ and hinders cell division. Altogether, this work reveals that RocS is the cornerstone of a nucleoid protection system ensuring proper chromosome segregation and cell division in coordination with the biogenesis of the protective capsular layer.
Pubmed
Web of science
Création de la notice
24/06/2019 7:18
Dernière modification de la notice
23/10/2019 5:13
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