The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases.
Details
Serval ID
serval:BIB_65E4DCA6F4DB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases.
Journal
Cell death and differentiation
ISSN
1350-9047 (Print)
ISSN-L
1350-9047
Publication state
Published
Issued date
11/2008
Peer-reviewed
Oui
Volume
15
Number
11
Pages
1804-1811
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
The outcome of a viral infection depends on the interplay between the host's capacity to trigger potent antiviral responses and viral mechanisms that counteract them. Although Toll-like receptor (TLR)-3, which recognizes virally derived double-stranded (ds) RNA, transmits downstream antiviral signaling through the TIR adaptor Trif (TICAM-1), viral RNA-sensing RIG-like helicases (RLHs) use the mitochondrial-bound CARD protein Cardif (IPS-1/MAVS/VISA). The importance of these two antiviral signaling pathways is reflected by the fact that both adaptors are inhibited through specific cleavage triggered by the hepatitis C virus serine protease NS3-4A. Here, we show that inactivation can also occur through cellular caspases activated by various pro-apoptotic signals. Upon caspase-dependent cleavage both adaptors loose their capacity to activate the transcription factors interferon regulatory factors (IRF) and NF-kappaB. Importantly, poliovirus infection triggers a caspase-dependent cleavage of Cardif, suggesting that some viruses may activate caspases not only as a mean to facilitate shedding and replication, but also to impair antiviral responses.
Keywords
Adaptor Proteins, Signal Transducing/metabolism, Adaptor Proteins, Vesicular Transport/metabolism, Antiviral Agents/metabolism, Caspases/metabolism, HeLa Cells, Humans, Interferon Regulatory Factors/metabolism, Models, Biological, Poliovirus/physiology, Protein Processing, Post-Translational
Pubmed
Web of science
Open Access
Yes
Create date
11/08/2020 16:45
Last modification date
08/02/2022 6:36